The death toll increased by a daily record of 232 to 4,374, while 159,257 people have recovered, including 8,264 over the last 24 hours, according to the statement.
Moscow, the country’s worst-hit region, confirmed 2,332 new cases in the last 24 hours, taking its total to 175,829.
As of Thursday, 305,061 people were under medical observation, Russia’s consumer rights and human well-being watchdog Rospotrebnadzor said in a statement Friday.
More than 10 million lab tests for COVID-19 have been conducted across the country so far, it added.
Experts believe that Russia has passed the peak of the pandemic, with some regions easing self-isolation regulations.
The Moscow Region no longer requires the use of electronic passes for travel around the region, though the city of Moscow itself will keep them until at least June 14.
On Thursday, Moscow Mayor Sergei Sobyanin said temporary hospitals created in the city for coronavirus patients will be mothballed in case infections rebound.