This followed the foot injury he suffered during their remarkable semi-final second leg victory over Ajax Amsterdam on Wednesday.
The Belgium international was pictured leaving the Johan Cruyff Arena aided by crutches and with his right foot in a protective boot.
Vertonghen played with a mask during Tottenham’s 3-2 second leg victory to protect his nose.
He had a sickening clash of heads with team mate Toby Alderweireld during the 1-0 loss in the first leg in London.
The 32-year-old completed the full 90 minutes in Amsterdam and helped the north London club secure a place in the final against Liverpool in Madrid on June 1.
Though Spurs have not yet commented on Vertonghen’s state, the injury puts him in doubt for the final English Premier League (EPL) game of the season against Everton on Sunday.
Mauricio Pochettino’s Spurs, currently fourth above Arsenal in the table, are all but assured of a UEFA Champions League qualification spot next year.